Health News
Tibial Plafond Fracture
A case of a tibial plafond fracture. Treatment of this tibial pilon fracture was with surgery to place a plate and screws on the bone to hold the broken fragments in position. (Source: About.com Eating Disorders) Perthes Disease
Legg Calve Perthes disease is a condition seen in children that causes hip pain. Often called Perthes disease, this condition is the result of a lack of blood flow to the bone around the hip joint. Treatment of Perthes disease may consist of observation, physical therapy, and occasionally surgery is needed. (Source: About.com Eating Disorders) Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver [Articles]
Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is difficult for various reasons, including species differences. However, chimeric mice with humanized liver (PXB mice; urokinase-type plasminogen activator/severe combined immunodeficiency mice repopulated with approximately 80% human hepatocytes) have been developed. The expression levels and metabolic activities of cytochrome P450 (P450) and non-P450 enzymes in the livers of PXB mice are similar to those in humans. In this study, we examined the predictability for human PK parameters from data obtained in PXB mice. Elimination of selected drugs involves multiple metabolic pathways mediated not only by P450 but also by non-P450 enzymes, such as UDP-glucuronosyltransferase, sulfotransferase, and aldehyde oxidase in liver. Direct comparison between in vitro intrinsic clearance (CLint,in vitro) in PXB mice hepatocytes and in vivo intrinsic clearance (CLint,in vivo) in humans, calculated based on a well stirred model, showed a moderate correlation (r2 = 0.475, p = 0.009). However, when CLint,in vivo values in humans and PXB mice were compared similarly, there was a good correlation (r2 = 0.754, p = 1.174 x 10–4). Elimination half-life (t1/2) after intravenous administration also showed a good correlation (r2 = 0.886, p = 1.506 x 10–4) between humans and PXB mice. The rank order of CL and t1/2 in human could be predicted at least, although it may not be possible to predict absolute values due to rather large prediction errors. Our results indicate that in vitro and in vivo experiments with PXB mice should be useful at least for semiquantitative prediction of the PK characteristics of candidate drugs in humans.
Return Home From Surgery
Having joint replacement surgery takes a lot of planning, but patients often forget about planning for their return home. After joint replacement surgery, including hip replacement or knee replacement, you may need some extra help around the house. Planning ahead can take the anxiety out of returning home from joint replacement surgery. (Source: About.com Eating Disorders) Study: People may lie more often when texting
Researchers suggest it's easier to deceive than when in person or during video chat (Source: USATODAY.com Health) ACL Tears in Children
ACL tears are a major knee injury that often requires surgical reconstruction of the torn ligament. When this injury occurs in a child, there is controversy about treatment with immediate surgery or a delay until adolescence. Should your child have ACL surgery? (Source: About.com Eating Disorders) losartan, Cozaar
Title: losartan, CozaarbrCategory: MedicationsbrCreated: 12/31/1997brLast Editorial Review: 1/4/2012 Cost puts dental care out of reach
SAN FRANCISCO, Jan. 28 (UPI) -- Dental expenses were among the highest out-of-pocket health expenditures for U.S. consumers in 2008, researchers say. (Source: Health News - UPI.com)
|